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Partial orchiectomy may be considered for lesions highly likely to be benign based on first and/or second level exams [301, 308, 309], especially if the tumor is small, the patient has an anatomically or functionally solitary testicle, or in case of bilateral synchronous malignancies

Additionally, certain antibiotics and anticonvulsants can increase B12 metabolism, reducing its efficacy period

This magnitude of weight loss narrows the gap with bariatric procedures, although it remains below the average 25%-35% weight loss typically reported after sleeve gastrectomy or Roux-en-Y gastric bypass [6] , reinforcing the therapeutic potential of dual-pathway targeting

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