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Reducing the risk of complications: B12 deficiency can contribute to heart disease, stroke, and neurological disorders

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What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data

Study design variability: Models and dosages differ widely between research groups

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Hair shedding during treatment is usually related to rapid weight loss, low protein intake, or nutrient stress, not medication toxicity