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Medical necessity generally means that a healthcare provider believes treatment is appropriate based on current health status, obesity-related medical conditions, health risks, previous treatment attempts, and potential benefits of treatment

a High-quality evidence from consistent RCTs or meta-analyses

By reducing appetite, promoting satiety, and influencing metabolic pathways, these medications directly address the mechanisms that contribute to weight gain

Yeo, Y.H

The 56-week COR-I trial studied the use of Contrave in patients with a BMI of 27 or higher and found that participants taking a combination of naltrexone and bupropion lost an average of 4.8% more weight than those given a placebo

Hasan AA, Hocher B