The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance
In their own words: "This systematic review offers important insights into the safety records of semaglutide, particularly highlighting gastrointestinal side effects and its negligible risk towards thyroid cancer." Effectively, while rodents developed thyroid tumors on semaglutide, so far, it does not seem like people react the same way
Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, et al
These modifications extended the half-life from 2 minutes (natural GLP-1) to 7 days (semaglutide)
The abdomen Most researchers and healthcare providers consider the abdomen the preferred injection site
Endocrinology 2010