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He comes down on the side of pragmatism

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Overweight is defined as body mass index of 27kg/m2 or greater and has one weight-related problem mentioned above or a BMI of 30 kg/m2 or greater

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IUPHAR/BPS Guide to Pharmacology

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Diabetes Care (2014) 37(10):288494.10.2337/dc14-0865 Summary Keywords CD26/DPP4, soluble DPP4, type 2 diabetes mellitus, incretins, DPP4 inhibitors/gliptins, multifunctional enzyme Citation Rhrborn D, Wronkowitz N and Eckel J (2015) DPP4 in Diabetes

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By coupling agonism at the GLP-1 receptor with simultaneous agonism at the GIP receptor, a related incretin whose physiological role had been the subject of decades of competing theories, Eli Lilly produced a molecule whose efficacy in trial conditions exceeded semaglutide by a margin too large to dismiss as noise or trial-design artifact

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