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However, it does not interact with GLP-1 pathways, Dr
Metab Brain Dis 36:13911401
Parthsarathy et al
When switching from another basal insulin to Toujeo, patients experienced higher average fasting plasma glucose levels in the first few weeks of therapy until titrated to their individualized fasting plasma glucose targets
10.1161/CIRCRESAHA.118.312673 67 PfefferM
GLP-1 specifically binds to the glucagon-like peptide-1 receptor (GLP-1R) in the body, directly stimulating the secretion of insulin by pancreatic -cells, promoting proliferation and differentiation, and inhibiting cell apoptosis, thereby exerting a glycemic lowering effect
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