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Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations (62), suggesting a role for AIP alterations in SS-resistance of sporadic GH-secreting adenomas
This included changing characteristics like the planets' sizes, the speed of their rotation, their internal heating, and the hardness of rotating fluid within their vortices
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limited human data reveal no teratogenicity at therapeutic doses, yet clinicians are advised to employ the lowest effective regimen
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