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Safety and immunogenicity of the -synuclein active immunotherapeutic PD01A in patients with Parkinsons disease: a randomised, single-blinded, phase 1 trial

Studies show that activation of the GLP-1 receptor in the brain reduces dopamine release from addictive substances such as nicotine and alcohol, leading to fewer cravings and reinforcement

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NNMT inhibition works on a timescale of weeks, not hours, so a missed day costs nothing measurable