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Compounded medications are not FDA-approved and do not have equivalent clinical trial data establishing the same safety, efficacy, or outcomes
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| Parameter | Orforglipron (oral pill) | Retatrutide (injectable peptide) | | --- | --- | --- | | Molecular class | Non-peptide small molecule | Peptide (amino acid chain) | | Receptor profile | GLP-1 (single target) | GIP + GLP-1 + glucagon (triple) | | Administration | Oral, tablet | Subcutaneous injection | | Interval | Once daily | Once weekly | | Half-life | Short (daily dosing) | approx
with one of the randomized, controlled trials contributing to its FDA approval demonstrating up to 8.2% weight loss
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placebo), la mayora de ellos (liraglituda, semaglutida SC, dulaglutida, albiglutida y efpeglenatida) han demostrado adems una reduccin de los MACE respecto a placebo, mientras exenatida semanal o semaglutida oral mostraron una tendencia a reducir los MACE
