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Excess inflammation degrades the very matrix the other three are trying to build

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8 Novel and Emerging Strategies Systemic Medications Fumaric acid esters

Reducing glutathione production in lymphoma cells, either through pharmacological inhibition of glutamate cysteine ligase (GCL), the enzyme catalyzing the rate-limiting step in glutathione biosynthesis, or via knockdown of GCLC , the GCL catalytic subunit, sharply decreased cell growth in 3D gels and xenografts

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(1999) identified this novel protein, Kelch-like ECH-associated protein1 (KEAP1), as the cytosolic negative regulator of NRF2 activity