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The clinical signs and symptoms of Melanotic Macules include the following: The presence of pigmented skin lesions/spots anywhere in the body

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These typically cause numbness in specific distributionsfor example, the thumb, index, and middle fingers in carpal tunnel syndrome

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A significant contributing factor to the prevalence of T2DM is obesity, which is strongly associated with serious consequences such as chronic kidney disease, hypertension, stroke, and liver disease that impair both the quality and quantity of life as life expectancy declines with rising body mass index (BMI) [2]