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Similarly, in a type 2 diabetes mellitus mouse model, SF (5.64 mol/kg/day for 28 days) administration mitigated cognitive decline and reduced pathological hallmarks of AD, such as A-oligomers, A 142 plaques, and phospho-tau (122)

Interestingly, riboflavin enhanced the effect of 400 g folic acid on circulating 5-methyltetrahydrofolate (5-MTHF) specifically in the polyp patients with the C677T genetic variant (45)

It is difficult to draw conclusions from the two studies, as their design and interventions differed

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Future investigation should also clarify whether the benefit is driven by direct antitumor effects of GLP-1 RAs or by indirect mechanisms mediated through weight loss and cardiometabolic risk reduction