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Furthermore, in a BK5.IGF-1 mouse model of breast cancer, elevated levels of IGF-1 expression activated the COX-2/PGE2/EP3 signaling pathway, accompanied by increased VEGF expression and tumor angiogenesis (110)
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Melanosis coli can be observed during endoscopic procedures that examine the large intestine, such as colonoscopy and sigmoidoscopy
When the acetyl-CoA generated from the beta-oxidation of fats enters the Krebs cycle, it undergoes a series of transformations, eventually reaching the stage where succinate is converted into fumarate by the enzyme succinate dehydrogenase
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