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Phase III clinical data from SCENESSE trials (the FDA-approved formulation of afamelanotide) demonstrated that patients with erythropoietic protoporphyria achieved clinically meaningful photoprotection after 60 days of sustained drug delivery via controlled-release implant

A C20 fatty di-acid moiety attached via a Glu2AEEA linker enables reversible serum albumin binding and extends the circulating half-life to approximately six days, supporting once-weekly research dosing protocols comparable to those used for tirzepatide and semaglutide

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