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Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine

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The Peptide Problem: Why Oral GLP-1 Was So Difficult Glucagon-like peptide-1 is a 30-amino-acid incretin hormone secreted by enteroendocrine L-cells in the distal small intestine in response to nutrient ingestion

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AOD9604 caused only a modest weight increase, which was statistically significant only on the last day of the 14-day treatment period