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111 Understanding how genetic and epigenetic, neurologic, hormonal, and immune mechanisms contribute to the experience of pain may help patients reconceptualize their condition, feel less anxious, and feel more empowered to make changes that can improve their outcomes

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However, for advanced experimental models, it can be combined with NAD+ (for mitochondrial redox optimization) or SS-31 (for enhanced mitochondrial membrane protection)

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This is Epithalons signature mechanism and the one most cited in longevity literature