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In the intestine for example, several drug metabolising enzymes are presumed to decrease the bioavailability of orally administered drugs or to activate environmental carcinogens

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It is either synthesized from -glutamyl-cysteine and glycine by glutathione synthetase (GSS) or recycled from glutathione disulfide by glutathione reductase (GSR) using NADPH as a reducing agent [33]

Kim SW, Kim S, Son M et al (2020) Melatonin controls microbiota in colitis by goblet cell differentiation and antimicrobial peptide production through Toll-like receptor 4 signalling