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The research, published Thursday in JAMA Ophthalmology, found that after one year, more than twice as many people on GLP-1 drugs developed neovascular age-related macular degeneration compared to similar people who were not taking the drugs
Individuals with type 2 diabetes often have impaired insulin function or insulin resistance
Neurons provide ATP mainly through mitochondrial oxidative phosphorylation (OXPHOS), glycolysis, and patients with cognitive impairment are associated with abnormalities in cerebral glucose utilisation as well as glycolysis and OXPHOS metabolism
The pattern suggests these drugs may work as prevention rather than treatment
doi: 10.1111/jdv.16064 14
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