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Preclinical trials conducted on rats demonstrate measurable improvements in transected tendon reattachment and Achilles tendon rupture models, though human clinical data remain limited

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Also, the investigators separately assessed patients with high baseline homocysteine levels (greater than 12 m/L) vs those with low levels (12 m/L or less)

Wound healing and tissue remodeling research goes back further and is more robust

It is important to note that the medical use of methandienone has been largely discontinued and withdrawn in most countries due to these strong side effects, and it is primarily used non-medically for performance enhancement, often illegally