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GIP (Glucose-Dependent Insulinotropic Polypeptide): Helps your body secrete insulin more effectively in response to meals

Our study may indicate that medication such as Wegovy could have a dual effect both through weight loss and by increasing GLP-1 levels in the joints, Kragstrup said

This aggressive initial dosing saturates tissues rapidly

Its safety profile is well-documented from years of real-world use

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For context, NICE guidance on existing approved GLP-1 receptor agonists for example, NICE TA875 (Semaglutide for managing overweight and obesity, 2023) acknowledges GI side effects as a recognised class effect and supports gradual dose escalation to improve tolerability