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Pharmacological Approaches Anti-spasmodics, including dicyclomine, hyoscyamine, and hyoscine, may reduce abdominal pain by relaxing intestinal smooth muscle, but can worsen constipation and lack strong evidence for IBS-C pain relief [104, 105]

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Moreover, studies conducted on animal models have shown that enteroendocrine L-cells increase the secretion of GLP-1 in response to inflammatory cytokines (e.g., interleukin-6 (IL-6) and lipopolysaccharide (LPS) (38)) and ischaemic injury (39)