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Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

This is likely due to the fact that, in the C1 metabolism model, not only are the effects on the formaldehyde detoxification being considered, but also its coupled effects with methionine biosynthesis and the activated methyl cycle

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The trial failed to demonstrate any statistically significant impact of semaglutide on retinal oxygenation or vascular diameter, arguing against a direct vasotoxic mechanism