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Folate deficiency during this period is associated with the development of autism spectrum disorders in children, neural tube irregularity, and brain development defects in the fetus and brain function in later life (20, 30, 68, 69)
OPA1, a key mitochondrial fusion regulator, is upregulated in multiple cancers, including AML and breast, colon, small cell lung, and stomach cancers (Fig
The MnFe 2 O 4 component of MFC-GEM depletes GSH, increases ROS levels, and enables pH-responsive release of gemcitabine in vivo
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[4] In patients with cyanide poisoning, hydroxocobalamin also acts as an antidote by binding to cyanide ions with high affinity to form nontoxic cyanocobalamin