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First, we tested whether microbial structures including bacterial muramyl dipeptide (MDP) and lipopolysaccharide (LPS) or the pro-inflammatory cytokines interferon (IFN) and TNF would induce GLP-1 secretion ( Figure 3A )

Anal Biochem 241:140142 Zalazar L, Saez Lancellotti TE, Clementi M, Lombardo C, Lamattina L, De Castro R, Forns MW, Cesari A (2012) SPINK3 modulates mouse sperm physiology through the reduction of nitric oxide level independently of its trypsin inhibitory activity

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However, it may cause less severe gastrointestinal issues than orlistat, which can lead to oily stools and gas

Pharmacological determinantsdose and durationgovern target engagement