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[3] The British Society for Haematology guidelines emphasise that the response to treatment should be monitored through clinical assessment and blood count testing, rather than routine measurement of B12 levels after treatment has started

References Wang W

I know there are quite a few variables with oral bioavailability, but assuming taken fasted,

B12 Injections One injection: $25 / Package of 5 injections: $100 Vitamin B12 is commonly used to treat deficiency caused by medical conditions and supplement those at risk including those who have vegans/vegetarian diets, are pregnant/lactating, or are older adults

The IM injection angle should be 90 degrees to the injection site

Some specific types, like methylcobalamin, might even need to be refrigerated