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Relative treatment effects of combination therapy assuming 50% additivity were modestly attenuated: MACE (HR, 0.73 [95% CI, 0.620.87]), heart failure hospitalization (HR, 0.53 [95% CI, 0.410.70]), CKD progression (HR, 0.51 [95% CI, 0.380.68]), cardiovascular death (HR, 0.73 [95% CI, 0.580.92]), and all-cause mortality (HR, 0.75 [95% CI, 0.630.90])

Blood glucose monitoring should increase to 4-6 times daily during the first month of combination therapy, with particular attention to pre-meal and bedtime readings

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The San Diego company is testing both an injectable and pill form