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it would not itself make retatrutide an approved medicine
They are not intended for human consumption
The ability to increase dose by 1.25 mg or 1.5 mg increments instead of 2.5 mg jumps reduces the "side effect cliff" that causes about 12% of patients to stop treatment during titration (Jastreboff et al., NEJM 2022)
Improved endothelial function with metformin in type 2 diabetes mellitus
Hannuniemi R et al
Patients should also be aware that feeling excessively cold could sometimes indicate inadequate nutrition or severe caloric restriction
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