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Organ-growth changes are believed to be largely irreversible, which is the strongest argument behind the 4-6 week cycle ceiling

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Their ability to improve endurance, stamina, recovery and overall performance makes them highly effective for endurance athletes

10.1016/j.lfs.2016.02.029 8 BarisicI.BalenovicD.KlicekR.RadicB.NikitovicB.DrmicD.et al (2013)

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These symptoms arise due to the bodys reduced ability to produce healthy red blood cells, leading to decreased oxygen supply to tissues