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Marys Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea 3 Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Yonsei University Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea 4 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea 5 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, South Korea 6 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea 7 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, South Korea 8 Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea 9 Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea 10 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea 11 Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea 12 Division of Pulmonary Medicine, Department of Internal Medicine, Chonnam National University Hospital, Gwangju, South Korea 13 Division of Pulmonary and Critical Care Medicine

5), indicating that protein synthesis is the predominant amino acid-consuming process in the cell

2 In this study, following 36 weeks of therapy with once weekly SC tirzepatide (10 or 15 mg), participants (n = 670) were randomized to continue tirzepatide or switch to placebo for an additional 52 weeks

The downregulation of protein arginine methyltransferase 7 (PRMT7) can inhibit ferroptosis in pulmonary epithelial cells caused by inflammatory monocytes, while PRMT7 promotes this process, thereby facilitating the adhesion and transmigratory migration of monocytes in patients with chronic obstructive pulmonary disease (COPD)[150]

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