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10.1016/j.cardfail.2007.06.721 63 MehtaS

doi: 10.4155/bio-2018-0091 Myler H, Pedras-Vasconcelos J, Phillips K, et al

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The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

Further changes involving receptor affinity and activation occurred specifically in monotremes

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