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For longer-standing issues, the full benefit typically develops over a complete 8-week cycle

10.1246/bcsj.48.2557

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Your provider may modify this schedule based on your response and tolerance

Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario

Fourteen of sixteen patients (87.5%) experienced significant pain relief