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As seen for the GIP receptor knockout mice, VLP-GIP efficiently reduced body weight gain in animals on a high-fat diet (69), supporting that the GIP receptor plays a role in developing obesity

If berberine or other lifestyle measures are insufficient, this genetic context can support a more informed conversation with your provider about whether compounded semaglutide, tirzepatide, or dual GLP-Squared formulations may be appropriate next steps

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Insulin doses typically need reduction of 20 to 50 percent when initiating tirzepatide to prevent hypoglycemia

This weight loss can lead to improved overall health outcomes, reducing the risk of complications associated with diabetes, such as cardiovascular disease and neuropathy