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In chronic neuroinflammation, microglia-targeting lipid nanoparticles (MG-LNPs) with siRNA payload have shown the therapeutic delivery of their payloads, as evidenced by improvements in reducing inflammation even when administered through non-optimal routes

Within this complex network, lymphatic endothelial cells (LECs) play a crucial role in regulating immune responses and influencing tumor progression and metastatic dissemination to lymph node and distant organs

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However, ongoing IV treatments can be costly and time-consuming, making them less practical for long-term use

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