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Nevertheless, a recent electrophysiological study on mouse cortical slices showed that D 4 R activation induces a more complex set of effects, with a direct slow decreasing effect on the excitability of P neurons and a fast and transient increase followed by a delayed decrease of the excitability of PV+ interneurons ( 4 R-mediated decrease excitability of P neurons

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For instance, future research may focus on exploring structureactivity relationships of NRF2 activators to identify more effective and selective compounds, while investigating their potential therapeutic applications across diverse disease models