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However, based on the clinical trial criteria used in studies such as the Phase 2 trial published in the New England Journal of Medicine (2023), researchers have investigated its use in adults with: Obesity , defined as a body mass index (BMI) of 30 kg/m or above Overweight (BMI 27 kg/m or above) with at least one weight-related comorbidity, such as hypertension, dyslipidaemia, or obstructive sleep apnoea Type 2 diabetes , where improved glycaemic control alongside weight reduction is a treatment goal In clinical trials, participants were typically adults without a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)
Nature 527 , 9599 (2015)
Is autophagy associated with diabetes mellitus and its complications
A., Novotny, E
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