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However, GPR40 but not GPR120 knockout mice exhibit impaired GLP-1 secretion from dietary fat, and only GPR40 agonists induce GLP-1 release in vitro and in vivo 106,110,111,112

Or as one obesity researcher, who has associations with the drugmaker and did not feel comfortable speaking on the record, put it: Given the majority of people accessing these medications are women, and a significant portion will be of childbearing age, this needs more attention. Its not yet clear why the birth complications in animals arise

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