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The rationale for combining these three peptides extends beyond simple additive effects to encompass true biological synergy, where coordinated activation of complementary pathways produces outcomes unattainable by individual components alone

Therefore, therapeutic strategies targeting intracellular regulatory environments may complement receptor-level interventions

Low levels of B12, especially during the first trimester, have been linked to neural tube defects (NTDs) such as spina bifida and anencephaly [*]

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