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Beyond purely enzymatic protection, the presence of Aib imposes severe biophysical restrictions on the backbone dihedral angles (specifically the phi and psi angles) of the peptide chain

The liver is the primary organ responsible for modifying toxins so that they can be excreted from the body

It regulates the synthesis of collagen

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Oxidation: Certain amino acid residues, particularly those with thiol or aromatic side chains, are vulnerable to oxidative damage from oxygen exposure and UV light