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Methods in Molecular Biology, vol 681

PMCID: PMC9160924

Initially derived from Melanotan IIa peptide known for its tanning effectsPT-141 was discovered to have significant potential in enhancing sexual desire, leading to its targeted use for libido enhancement

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Local inhibitory network GIPR-expressing neurons in the dorsal vagal complex (AP/NTS) are predominantly GABAergic with Gad1/Gad2 co-expression