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These heterogeneous responses are modulated by multiple factors, including tumor classification, study methodology, treatment duration, and patient-specific parameters (Table 1)

These findings underscore the importance of ongoing pharmacovigilance and the need for long-term observational studies and randomized controlled trials

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It is possible to regain weight if healthy lifestyle habits are not maintained after discontinuing medication

Some stop because of side effects, coverage, cost, or life circumstances

In TRIUMPH-1, the most common adverse events with retatrutide (4 mg, 9 mg, 12 mg vs