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After synthesis, the peptide is purified using high-resolution chromatography, most commonly HPLC , to remove impurities and byproducts

In order to compare the current analysis with the analysis conducted using phase 3 data, a one-compartment model was estimated using data from seven of the clinical pharmacology trials (Table 1) which employed multiple doses of the semaglutide drug product used in the phase 3 trials

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