It has been proposed that overexpression of GPX8 reduces Ca 2+ storage and histamine-induced Ca 2+ release in the endoplasmic reticulum (Yoboue et al., 2017)
Foods rich in sulfur can help support glutathione production
Additional topical options demonstrate varying mechanisms: Kojic acid 1-4%: Daily application with moderate tyrosinase inhibition Vitamin C serum 10-20%: Daily application with weak to moderate tyrosinase inhibition Tranexamic acid 2-5%: Twice daily application using anti-inflammatory mechanisms Systematic reviews document superior efficacy with combination therapy using oral plus topical glutathione versus monotherapy
Why Tablets Are a Practical Daily Choice Glutathione tablets do not require clinic visits or medical supervision
doi: 10.3389/fphar.2025.1737199 Received 01 November 2025 Revised 21 December 2025 Accepted 29 December 2025 Published 15 January 2026 Volume 16 - 2025 Edited by Dawei Chen, University of Kiel, Germany Reviewed by Eveljn Scarian, University of Pavia, Italy Hong Cheng, Yangzhou University, China Updates Copyright 2026 Knudsen, Tadje, Coggins and Venketaraman
Autophagy 10 (2), 386387
