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It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
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The introduction of oral formulations and improved supply capacity are expected to accelerate market penetration across major developed markets
doi:10.1016/S0140-6736(19)31271-1 30
Advances in therapy, 38(6), 28212839
Instead, we treat it as a powerful tool for a total metabolic reset
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