In mice at thermoneutrality, repeated dosing increases energy expenditure, lowers RER, reduces fat mass and adipocyte size, and improves hepatic lipid metrics
[4] To clear about 95% of a drug, it usually takes around five half-lives
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Plus, if a doctor prescribes a more effective weight loss medication, it may not be covered by the patients insurance
Skipping ahead to a higher dose increases the chance of severe GI side effects