tirzepatide blood brain barrier shows neuroprotective effects via regulating glucose metabolism in APP/PS1 mice Crossing the blood-brain barrier to

Elife 8 , e45572 (2019)

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As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36

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Do not discontinue GLP-1 therapy without medical advice if you develop ED, as the benefits of these medications for diabetes control and cardiovascular risk reduction are substantial, and ED is unlikely to be directly caused by the medication itself

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