The majority of these follow-on patent applications and granted patents cover minor modifications in the form of delivery devices, formulations and methods of treatment
Additionally, in the trial examining alcohol use disorder, a significant reduction in alcohol consumption was observed only in a specific subgroup of patients with obesity, suggesting that patient characteristics, such as BMI, might influence treatment outcomes
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Ann N Y Acad Sci.2004;1033(1):108-116
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For the most part, milk thistle is safe for short-term use at recommended doses, but safety beyond a few months has not been established