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A meta-analysis reported that T2DM patients treated with GLP-1RAs have a lower risk of Alzheimers disease than non-users (OR = 0.54, 95% CI, 0.300.96) [273]

A 2022 systematic review and meta-analysis in JAMA Internal Medicine found increased rates of gallbladder or biliary disease among GLP-1 receptor agonist users compared to placebo or active comparators, with higher risk at weight-loss doses

As a consequence of GSH-deficiency, total B cells showed higher cytosolic and mitochondrial ROS (Supplementary Fig

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Tumor-associated macrophages and fibroblasts may secrete IGF to activate IGF-IR in cancer cells thereby promoting chemoresistance and radioresistance [187, 188]

Current evidence suggests the opposite