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Collectively, our data reveal that Y37P substitution in Cagri (from Amy) promotes differential engagement of the Cagri peptide with each RAMP that contributes to distinct conformational dynamics from those observed for each individual rAmy-bound AMYR complex

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That is the approach that produces the best long-term results with the least stress

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The even better news is that together these have the potential to be of considerable help

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