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3a), recapitulating our observations in vivo and demonstrating a cell-intrinsic role for vitamin B 12 in reprogramming

Clinical observations suggest the combination may produce enhanced metabolic effects through complementary pathway activation, though formal human trials combining these specific agents remain limited as of 2026

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Gastrointestinal effects such as nausea, vomiting, and diarrhea may arise, particularly at the start of treatment or after a dose increase