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These medications are expensive [11], are likely to require long-term use, and scaling up provision could place a heavy burden on NHS budgets already strained by the management of chronic conditions and recent structural reorganisations [64]

Thymol-1,5-disubstituted pyrazole hybrids and novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives exhibit inhibitory potential against both COX-2 and 5-LOX enzymes and possess anti-inflammatory properties (216, 217)

Micheletti R et al

Dynein mutations impair autophagic clearance of aggregate-prone proteins

Topical application targets localized skin concerns

Bibcode:2002FEBSL.511..145R